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Solubility: DMSO up to 100 mM
6(259):259ra145
EPZ-6438 was orally dosed to mice at 250-500 mg/kg twice per day for 21-28 days
is a potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with IC50 value of 5nM
Baricitinib - CAS# 1187594-09-7 dine HCl Solubility: DMSO up to 100Baricitinib, CAS No. 1187594 09 7, also known as INCB028050 or LY3009104, is a selective orally bioavailable JAK1 JAK2 inhibitor with nanomolar potency against JAK1 (5. 9 nM) and JAK2 (5. 7 nM). INCB028050 inhibits intracellular signaling of multiple proinflammatory cytokines including IL 6 and IL 23 at concentrations <50 nM. INCB028050 was also effective in multiple murine models of arthritis, with no evidence of suppression of humoral immunity or
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