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Smiles: C/C(/CCC(O)C(C)(C)O)=C\COC1C2C=COC=2C=C2OC(=O)C=CC2=1
CAS Number: 117976-90-6
[6]-gingerol treatment is shown to restore impaired intestinal barrier function and to suppress proinflammatory responses in DSS-treated Caco-2 monolayers
also known as Pelabresib
UMB-32 Catalog No.:M22476-C Smiles: C/C(/CCC(O)C(C)(C)O)=C\COC1C2C=COC=2C=C2OC(=O)C=CC2=1UMB 32 is a potent, selective inhibitor of the BET bromodomain BRD4 . The BET family (BRD2, BRD3, BRD4, and BRDT) functions as transcriptional coactivator proteins. BET bromodomains are also important mediators of cell cycle progression and facilitate developmental transitions such as spermiogenesis. Deregulation of BET bromodomain function has been observed in numerous malignancies. BET bromodomain inhibition has contributed new insights into gene