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Smiles: ONC(=O)CCCCCCC(=O)NC1C=CC=CC=1
2011 Jan 19
inhibiting conditioned avoidance responding in both rats and mice
specifically at 305 μM
RX-3117 - CAS# 865838-26-2 Catalog No.:M11354-10 Smiles: ONC(=O)CCCCCCC(=O)NC1C=CC=CC=1RX 3117, also known as TV 1360 and fluorocyclopentenylcytosine, is an orally available and potent DNA synthesis inhibitor with potential antineoplastic activity. Upon administration, the cytidine analogue RX 3117 is taken up by cells through a carrier mediated transporter, phosphorylated by uridine cytidine kinase (UCK) and then further phosphorylated to its diphosphate (RX DP) and triphosphate forms (RX TP). The triphosphate form is incorporated into
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