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VH298 can activate the HIF-1 signalling pathway by stabilizing both forms of HIF-1α in vitro
Pedersini R
Wurmbrand AP
Bardoxolone blocks the cellular synthesis of inducible nitric oxide synthase and inducible COX-2 in INF-γ-activated mouse macrophages with an IC50 value of 0
WAY-362450 atran etexilate mesylate VH298 can activate the HIF-1Turofexorate isopropyl, also known as WAY 362450 and XL335, is a highly potent, selective, and orally active agonist of the farnesoid X receptor (FXR) (EC(50) = 4 nM, Eff = 149%), which attenuates liver inflammation and fibrosis in murine model of non alcoholic steatohepatitis. Product information CAS Number: 629664 81 9 Molecular Weight: 438. 47 Formula: C25H24F2N2O3 Chemical Name: propan 2 yl 3 (3,4 difluorobenzoyl) 1,1 dimethyl 1H,2H,3H,6H
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