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Rocuronium (0
Formula: C18H14Cl2N2O2
Smiles: CCC1=CC2C(=O)C(=COC=2C(CN2CCCCC2)=C1O)C1=NC2=CC=CC=C2S1
Tripterine
MS 154 AC Bcl2 degrader-1 Rocuronium (0MS 154 is a potent and selective cereblon recruiting Degrader (PROTAC) of mutant epidermal growth factor receptor (EGFR), comprising a cereblon binding moiety joined by a linker to gefitinib. MS 154 decreases EGFR protein levels, inhibits downstream signaling in and inhibits proliferation of mutant EGFR bearing lung cancer cells (DC50 values are 11 and 25 nM in HCC 827 and H3255 cells, respectively; Dmax > 95% at 50 nM), but not in WT EGFR bearing
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