Oleyloxyethyl Phosphorylcholine r Conjugates 6 hydrochloride Doxorubicin-SMCC is a drug-linker conjugate

Doxorubicin-SMCC is a drug-linker conjugate for ADC

3C5H13NO/c15-1-4-6(16)7(17)10(19-4)14-3-13-5-8(14)11-2-12-9(5)18

2 µM and 10 µM

Formula: C19H41O12P

Oleyloxyethyl Phosphorylcholine r Conjugates 6 hydrochloride Doxorubicin-SMCC is a drug-linker conjugateIC50: 6. 2 M for porcine pancreatic PLA2 Oleyloxyethyl phosphorylcholine is a PLA2 inhibitor. Phospholipases A2 (PLA2s) are enzymes releasing fatty acids from glycerol. This particular phospholipase can specifically recognize the sn 2 acyl bond of phospholipids and catalytically hydrolyze the bond releasing arachidonic acid and lysophosphatidic acid. Upon downstream modification by cyclooxygenases, arachidonic acid is modified into active eicosanoids,