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CAS Number: 105628-72-6
WO 2018136700 A1 20180726
despite target engagement
InChiKey: HFYMDQMXVPJNTH-VQHVLOKHSA-N
Losartan Carboxaldehyde 6681509 CAS Number: 105628-72-6Losartan is an inhibitor of endothelial cyclooxygenase (COX) 2. COX 2 produces prostaglandins that inhibit apoptosis and stimulate angiogenesis and invasiveness, and thus selective COX 2 inhibitors can reduce prostaglandin synthesis and restore apoptosis. In vitro: Losartan is an intermediate aldehyde metabolite of losartan, the angiotensin II type 1 receptor antagonist. Losartan could not block angiotensin receptors, but inhibit the expression of
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