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460(2):333-40
8a-dimethyl-3-methylenenaphtho(2
5-dioxopyrrolidin-1-yl 6-(2
InChiKey: ONIQOQHATWINJY-UHFFFAOYSA-N
SJF 8240 Catalog No.:M7582-2 460(2):333-40c MET PROTACDegrader. Comprises MET inhibitor foretinib (GSK 1363089; Cat. No. 6056) joined by a linker to a von Hippel Lindau (VHL) recruiting ligand. Degrades c MET within 6 hours in vitro. Inhibits agonist driven AKT phosphorylation and GTL16 cell proliferation (IC50 = 66. 7 nM). Also degrades exon 14 deleted c MET in Hs746T cells. Product information CAS Number: 2230821 68 6 Molecular Weight: 1106. 24 Formula: C58H65F2N7O11S Synonym: SJF 8240
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