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SAR 407899
Lancet Oncol
5-dimethyl-2-nitrophenyl)furan-2-yl)methylene)-3-methyl-5-oxo-4
RA190 stabilized targets of human papillomavirus (HPV) E6 oncoprotein
AG-1517 - CAS# 153436-54-5 Catalog No.:M6400-10 SAR 407899AG 1517, CAS No. 153436 54 5, is a ATP competitive EGFR inhibitor with an IC50 and Ki of 25 and 6 pM. PD153035 effectively blocks the enhancement of mitogenesis, induction of early gene expression, and oncogenic transformation that occur in response to EGF receptor stimulation. With human fibroblasts and epidermoid carcinoma cells, PD153035 at nanomolar concentrations rapidly inhibits EGFR autophosphorylation. With breast and ovarian cancer cells,