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blocks aortic contraction with an IC50 of 0
25)/b21-17+/t13-
CAS Number: 2376146-48-2
Abstract DDT02-03: Discovery of GDC-0994
PF-622 xy-2-phenethylchromone blocks aortic contraction with anPF 622 is a potent, time dependent, irreversible FAAH inhibitor . Fatty acid amide hydrolase (FAAH), belongs to a member of an unusual class of serine hydrolases, is an integral membrane enzyme involved in regulating the fatty acid amide family of lipid transmitters. Genetic or pharmacological inactivation of FAAH leads to elevated endogenous levels of fatty acid amides with analgesic, anti inflammatory, anxiolytic, and antidepressant phenotypes. The
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