PROTAC BRD2/BRD4 degrader-1 in C It induces relaxation of isolated

It induces relaxation of isolated rat aorta and inhibits calcium-induced contraction of rabbit ear artery

Oral administration of Motesanib twice daily or once daily potently inhibits

InChi: InChI=1S/C22H27FN4O2

Smiles: C[C@H]1CC=CC(=O)[C@@H](O)[C@@H](O)C[C@H]2O[C@@H]2C2=CC(=CC(O)=C2C(=O)O1)OC |c:3|

PROTAC BRD2/BRD4 degrader-1 in C It induces relaxation of isolatedPROTAC BRD2 BRD4 degrader 1 (compound 15) is a potent and selective BET protein BRD4 and BRD2 degrader. PROTAC BRD2 BRD4 degrader 1 rapidly induces reversible, long lasting, and unexpectedly selective removal of BRD4 and BRD2 over BRD3. It effectively inhibits solid tumors with low cytotoxic effect. PROTAC BRD2 BRD4 degrader 1 is composed of the BET inhibitor, a linker, and the ligand thalidomide for cereblon (CRBN) cullin 4A. Product information