Tankyrase Inhibitors (TNKS) 22 halin 661W cells) treatment significantly increases

661W cells) treatment significantly increases cellular viability after serum deprivation and so it is demonstrated that Norgestrel is neuroprotective to stressed 661W cells

Smiles: CNC1=NC=NC2=C1N=CN2[C@H]1C[C@H](O)[C@@H](COC(C2=CC=CC=C2)(C2=CC=C(C=C2)OC)C2=CC=C(C=C2)OC)O1

Formula: C77H96ClF3N10O10S4

AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6

Tankyrase Inhibitors (TNKS) 22 halin 661W cells) treatment significantly increasesTankyrase Inhibitors (TNKS) 22 is a potent, selective and orally bioavailable inhibitor of tankyrase with IC50 value of 0. 1nM . Tankyrase 1 and tankyrase 2 are members of PARP family. They can use NAD+ as substrates to transfer ADP ribose polymers onto tagert proteins. The tankyrase are found to bind to PARSylate axin proteins which are the negative regulator of Wnt pathway. It makes tankyrase to be targets in treatment for adenomatous polyposis