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E-7449 shows no obvious inhibiotry effects on PARP3 or PARPs 6-16
Formula: C22H28N2O3
Potent inhibitor of T315l mutant and wild-type Abl kinases (IC50 values are 9 and 20 nM
9(3):268-273
FK 866 hydrochloride emodin E-7449 shows no obvious inhibiotryFK 866 hydrochloride is an inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase) with IC50 values ranging between 0. 09nM and 27. 2nM . NAD plays a vital role in numerous biochemical and biologic processes. Targeting NAD synthesis is thought to be a selective manner to kill cancer cells since cancer cells have a higher rate of NAD turnover compared with normal cells. In the vitro MTT assay using a panel of 41 human hematologic cancer cell
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